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Starling developed the term endocrine to distinguish the functions of hormones secreted internally (endocrine) from those secreted externally (exocrine) or into a lumen, such as the gastrointestinal tract. The term hormone, which comes from a Greek phrase meaning "to set in motion," accurately captures hormones' dynamic functions as they stimulate cellular responses and regulate physiological processes via feedback mechanisms. Endocrine deficiency disorders are treated with physiologic hormone replacement, while hormone excess problems, which are typically caused by benign glandular adenomas, are treated surgically or medically by lowering hormone levels.
